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Arch Dis Child 1998 Mar;78(3):273-4

Thrombocytopenic purpura as adverse reaction to recombinant hepatitis B vaccine.

Ronchi F, Cecchi P, Falcioni F, Marsciani A, Minak G, Muratori G, Tazzari PL, Beverini S.
Divisione Pediatrica-Ospedale Civile di Cattolica (RN), Cattolica (RN), Italy.

Three cases of immune thrombocytopenic purpura after the first dose of recombinant hepatitis B vaccine occurred in infants under 6 months of age. Other possible causes of this condition were excluded. Antiplatelet antibodies were present. A defect in platelet production was excluded in two children. Corticosteroid treatment was effective. Subsequent administration of other vaccines (against polio, diphtheria, and tetanus) did not cause relapse of thrombocytopenia.

PMID: 9613364